IMMUNOTHERAPY FOR COCCIDIOIDAL GRANULOMA

Abstract

The treatment of coccidioidal granuloma is of general clinical interest. The endemic character of the infection in certain localities, together with its frequently serious clinicopathologic manifestations and effects, constitutes a challenging demand for effective therapeutic efforts. That such efforts have heretofore proved only partially successful may be readily gleaned from a survey of the available literature dealing with the subject. This will reveal a large variety of therapeutic agents employed in the management of the disease and a correspondingly large variety of contradictory claims of success and failure resulting from their exhibition by the different clinicians. REVIEW OF THE LITERATURE Guy and Jacob¹obtained successful therapeutic results in a case of tuberculosis and coccidioidal granuloma by roentgen irradiation of the lesions and intravenous injections of a 1 per cent solution of antimony and potassium tartrate. The injections were administered on alternate days in increasing doses, commencing with 1 cc.