Intestinal transport of certain N-substituted amino acids
- 1 October 1962
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 203 (4), 637-640
- https://doi.org/10.1152/ajplegacy.1962.203.4.637
Abstract
Sarcosine, N,N-dimethylglycine and betaine were transported against concentration gradients by everted sacs of hamster small intestine. These compounds shared a common transport system which differed from that which acted on most neutral l-amino acids. The N-methyl derivatives of glycine, while competing with each other, had no effect on the transport of l-valine. Furthermore, l-valine and l-methionine, which were powerful inhibitors of the transport of most other neutral l-amino acids, had little effect on the absorption of betaine. Two other N-substituted amino acids, l-proline and hydroxy-l-proline, possessed affinity for both transport systems, a greater affinity being shown for the betaine carrier than for the neutral amino acid carrier. It is postulated that the transport system for N-substituted amino acids is important for the absorption of l-proline and hydroxy-l-proline in vivo.Keywords
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