Effect of Lactate on Renal Tubular Transfer of p-Aminohippurate in Man

Abstract

The intravenous administration of sodium lactate causes a statistically significant increase in Tm_PAH in man. The average maximum increase amounted to 30% of the preinjection levels, and the effect was observed in each of 8 subjects tested twice. Neither the observed increases in pH₈ and (BHCO₃) nor the changes in renal blood flow appear to bear a causal relationship to the increases in Tm_PAH produced.