Phenotypic transformation of clonal myogenic cells to cells resembling chondrocytes.
- 1 June 1976
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 73 (6), 1989-1993
- https://doi.org/10.1073/pnas.73.6.1989
Abstract
The nicotinamide analogue 6-aminonicotinamide and dibutyryl cyclic AMP inhibit myogenesis in a clonal rat cell line from skeletal muscle. Both reagents produce a similar morphological response in the cells, and stimulate collagen and glycosaminoglycan synthesis. 6-Aminonicotinamide and dibutyryl cyclic AMP may induce a phenotypic transformation of myogenic cells to cells that share many characteristics with chondrocytes.This publication has 35 references indexed in Scilit:
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