Quantitative structure-activity relationships: the Van't Hoff heats of transfer of resorcinol monoethers from water to n-octanol

Abstract

The partition coefficients of resorcinol and some resorcinol monoalkyl-ethers from water to n-octanol have been measured as a function of temperature. These data are used to evaluate ΔG, ΔH and ΔS for the solute transfer process. The data suggest direct calorimetric measurement of these parameters should be performed. Correlation with calori-metrically determined ‘biological response’ will permit a more detailed and precise commentary upon the quantitative structure-activity relationships for these compounds.