Frequent allelic loss and homozygous deletion in chromosome band 8p23 in oral cancer
Open Access
- 5 January 1999
- journal article
- research article
- Published by Wiley in International Journal of Cancer
Abstract
Frequent loss of heterozygosity on chromosome 8p in a variety of human malignancies, including head and neck cancers, has suggested the presence of a tumor suppressor gene (or genes) associated with the pathogenesis of these cancers. To test the role of genetic alterations at 8p23 in oral carcinogenesis, we studied 51 squamous cell carcinomas of the head and neck and 29 oral squamous cell carcinoma cell lines for allelic loss using 7 microsatellite markers spanning approximately 5 cM of chromosome band 8p23. Twenty‐three of 51 tumors (45%) and 23 of 29 cell lines (79%) showed allelic loss at 1 or more loci. Three cell lines showed homozygous deletion of loci within a 3 cM region defined by the markers D8S1781 and D8S262. Our results suggest that a tumor suppressor gene (or genes) is located in 8p23 and is associated with the development and/or progression of oral carcinomas. Int. J. Cancer 80:25–31, 1999.This publication has 13 references indexed in Scilit:
- Chromosome 8 Allelic Loss and the Outcome of Patients With Squamous Cell Carcinoma of the Supraglottic LarynxJNCI Journal of the National Cancer Institute, 1996
- Evidence for multiple tumor suppressor genes on chromosome arm 8p in supraglottic laryngeal cancerGenes, Chromosomes and Cancer, 1996
- A comprehensive genetic map of the human genome based on 5,264 microsatellitesNature, 1996
- Loss of heterozygosity of the short arm of chromosomes 3 and 9 in oral cancerInternational Journal of Cancer, 1996
- Rising trends of oral cancer mortality among males worldwide: the return of an old public health problemCancer Causes & Control, 1994
- Recurrent cytogenetic abnormalities in squamous cell carcinomas of the head and neck regionGenes, Chromosomes and Cancer, 1994
- Polymerase chain reaction–based restriction fragment length polymorphism analysis of the short arm of chromosome 3 in primary head and neck squamous carcinomaCancer, 1993
- Consistent chromosomal anomalies in keratinocyte cell lines derived from untreated malignant lesions of the oral cavityGenes, Chromosomes and Cancer, 1993
- Oral cancer in Scotland: changing incidence and mortality.BMJ, 1992
- Deletions in the short arm of chromosome 8 are present in up to 90% of human colorectal cancer cell linesGenes, Chromosomes and Cancer, 1992