The effect of methotrexate on intracellular folate pools in human MCF-7 breast cancer cells. Evidence for direct inhibition of purine synthesis.
Open Access
- 1 May 1986
- journal article
- research article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 261 (14), 6478-6485
- https://doi.org/10.1016/s0021-9258(19)84587-8
Abstract
No abstract availableThis publication has 37 references indexed in Scilit:
- Intracellular pharmacokinetics of methotrexate polyglutamates in human breast cancer cells. Selective retention and less dissociable binding of 4-NH2-10-CH3-pteroylglutamate4 and 4-NH2-10-CH3-pteroylglutamate5 to dihydrofolate reductase.JCI Insight, 1983
- Synthesis, Retention, and Biological Activity of Methotrexate Polyglutamates in Cultured Human Breast Cancer CellsJCI Insight, 1982
- Direct transfer of one-carbon units in the transformylations of de novo purine biosynthesisBiochemistry, 1982
- On the cofactor specificity of glycinamide ribonucleotide and 5-aminoimidazole-4-carboxamide ribonucleotide transformylase from chicken liverBiochemistry, 1981
- Extracellular recovery of methotrexate-polyglutamates following efflux from L1210 leukemia cellsBiochemical Pharmacology, 1980
- Interactions of pig liver methylenetetrahydrofolate reductase with methylenetetrahydropteroylpolyglutamate substrates and with dihydropteroylpolyglutamate inhibitorsBiochemistry, 1980
- Human thymidylate synthetase—IIIBiochemical Pharmacology, 1979
- Folylpoly-.gamma.-glutamates as cosubstrates of 10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferaseBiochemistry, 1979
- Polygammaglutamyl metabolites of methotrexateBiochemical and Biophysical Research Communications, 1973
- FORMATION OF 4-AMINO-5-CARBOXAMIDOIMIDAZOLE DURING GROWTH OF ESCHERICHIA COLI IN THE PRESENCE OF 4-AMINOPTEROYLGLUTAMIC ACIDJournal of the American Chemical Society, 1950