Glycerol-induced hemoglobinuric acute renal failure in the rat. I. Micropuncture study of the development of oliguria.

Abstract

The cause of oliguria in hemoglobinuric acute renal failure was investigated by micropuncture techniques. Glomerular filtration rate of individual nephrons was markedly diminished in oliguric animals. This was not due to obstruction with either casts or interstitial edema, intratubular pressure being greatly reduced. Increased water absorption in the proximal tubule was not found, fractional absorption being normal or decreased. As judged by blood flow in peritubular capillaries of nephrons studied, glomerular perfusion was apparently near normal, elimination vascular shunts as a cause of cessation of glomerular filtration rate which is attributed, therefore, to alterations in glomerular afferent-efferent arteriole tone. The possible role of the renin-angiotensin axis in the development of oliguria of acute renal failure is considered.