Interferometric technique to measure biomechanical changes in the cornea induced by refractive surgery
- 1 January 2005
- journal article
- Published by Wolters Kluwer Health in Journal of Cataract & Refractive Surgery
- Vol. 31 (1), 175-184
- https://doi.org/10.1016/j.jcrs.2004.10.038
Abstract
Purpose: To develop a technique to quantify biomechanical changes in the cornea after microkeratome incisions as would be performed in laser in situ keratomileusis. Setting: St Thomas' Hospital, London, and the Wolfson School of Mechanical and Manufacturing Engineering, Loughborough University, Loughborough, United Kingdom. Methods: Corneal displacements of whole sheep eyes were studied under hydrostatic loading using electronic speckle pattern interferometry before and after microkeratome incisions. Results: After hydrostatic loading, there was a 20.7% increase in corneal displacement in corneas with microkeratome incisions compared to unoperated corneas; this was statistically significant (P = .0068, unpaired t test). Conclusions: Results show that in the formation of the microkeratome flap, collagen fibers are severed and minimal biomechanical loading is distributed through the flap. Corneal biomechanical integrity is compromised after microkeratome incisions.Keywords
This publication has 22 references indexed in Scilit:
- X-Ray Scattering Used to Map the Preferred Collagen Orientation in the Human Cornea and LimbusStructure, 2004
- Collagen Fibrils Appear More Closely Packed in the Prepupillary Cornea: Optical and Biomechanical ImplicationsInvestigative Opthalmology & Visual Science, 2003
- Corneal ectasia induced by laser in situ keratomileusisJournal of Cataract & Refractive Surgery, 2001
- Corneal ectasia after laser in situ keratomileusisJournal of Cataract & Refractive Surgery, 2001
- A comparison of biomechanical properties between human and porcine corneaJournal of Biomechanics, 2001
- Iatrogenic keratectasia after laser in situ keratomileusis for less than −4.0 to −7.0 diopters of myopiaJournal of Cataract & Refractive Surgery, 2000
- Corneal ectasia detected after laser in situ keratomileusis for correction of less than −12 diopters of myopiaJournal of Cataract & Refractive Surgery, 2000
- Delayed onset keratectasia following laser in situ keratomileusisJournal of Cataract & Refractive Surgery, 1999
- Strip Extensiometry for Comparison of the Mechanical Response of Bovine, Rabbit, and Human CorneasJournal of Biomechanical Engineering, 1992
- Photorefractive keratectomy: A technique for laser refractive surgeryJournal of Cataract & Refractive Surgery, 1988