Effect of hyperosmolarity on resting and developed tension in heart muscle
- 1 March 1977
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Cell Physiology
- Vol. 232 (3), C155-C162
- https://doi.org/10.1152/ajpcell.1977.232.3.c155
Abstract
Simultaneous changes in weight, tension, and electrical activity were studied in the isolated perfused rabbit heart when the Ringer solution perfusion fluid was made hypertonic by the addition of sucrose, urea, glycerol, ethylene glycol, or formamide. The typical responses to each of the molecules was an initial drop in weight and tension followed by a return toward the base-line level. A 0.4 M concentration of sucrose, urea, or glycerol reduced the weight to 40 +/- 4.6, 48 +/- 3, and 52.2 +/- 3% of the initial value, respectively. The tension was simultaneously reduced to 23 +/- 3.5, 31 +/- 2, and 41 +/- 4% of its initial value. The tension drop produced by the solutes tested was linearly related to the amount of water lost by the heart. The falling phases of both tension and weight loss were closely correlated phases of both tension and weight loss were closely correlated in time a magnitude and were both related to the effectiveness of a particular molecule to move water out of the cells. In contrast, the subsequent rising phases of tension and weight were not as well correlated in time and magnitude. Whereas for most of the molecules used, the tension recovery was incomplete; urea, in contrast, caused an overshoot of the control tension level, thus pointing toward a unique inotropic effect of this compound. Resting tension rose for both urea and sucrose but not for the other compounds.This publication has 21 references indexed in Scilit:
- Tension in Skinned Frog Muscle Fibers in Solutions of Varying Ionic Strength and Neutral Salt CompositionThe Journal of general physiology, 1973
- Evaluation of Several Geometric Models for Estimation of Left Ventricular Circumferential Wall StressCirculation Research, 1973
- Some Effects of Hypertonic Solutions on Contraction and Excitation-Contraction Coupling in Frog Skeletal MusclesThe Journal of general physiology, 1970
- Caffeine-induced contractures and related calcium movements of muscle in hypertonic mediaCellular and Molecular Life Sciences, 1969
- Permeability Characteristics of Vascular Smooth Muscle Cells as Revealed by Their Osmotic Responses to Non‐ElectrolytesActa Physiologica Scandinavica, 1969
- Volume and Twitch Tension Changes in Single Muscle Fibers in Hypertonic SolutionsThe Journal of general physiology, 1968
- Osmotic volume changes induced by a permeable soluteJournal of Theoretical Biology, 1967
- Influence of osmolarity of perfusate on contractility of mammalian myocardiumAmerican Journal of Physiology-Legacy Content, 1963
- Chemical and histological space determinations in rabbit heartAmerican Journal of Physiology-Legacy Content, 1962
- Potassium flux in the isolated perfused rabbit heartAmerican Journal of Physiology-Legacy Content, 1960