IL-33 and IL-33 Receptors in Host Defense and Diseases
Open Access
- 1 January 2010
- journal article
- review article
- Published by Japanese Society of Allergology in Allergology International
- Vol. 59 (2), 143-160
- https://doi.org/10.2332/allergolint.10-rai-0186
Abstract
Interleukin-33 (IL-33) is a member of the IL-1 cytokine family, which includes IL-1 and IL-18. IL-33 is considered to be crucial for induction of Th2-type cytokine-associated immune responses such as host defense against nematodes and allergic diseases by inducing production of such Th2-type cytokines as IL-5 and IL-13 by Th2 cells, mast cells, basophils and eosinophils. In addition, IL-33 is involved in the induction of non-Th2-type acute and chronic inflammation as a proinflammatory cytokine, similar to IL-1 and IL-18. In this review, we summarize and discuss the current knowledge regarding the roles of IL-33 and IL-33 receptors in host defense and disease development.Keywords
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