Enhanced casein kinase II activity in human tumour cell cultures
- 29 October 1984
- journal article
- Published by Wiley in FEBS Letters
- Vol. 176 (2), 479-483
- https://doi.org/10.1016/0014-5793(84)81222-3
Abstract
Casein kinase II (CKII) activity is enhanced as much as 2–3 fold in established and 4–5-fold in transformed human cell lines when compared to that of fibroblasts and primary human tumour cell cultures where CKII activity never exceeded a basic level. The high activity of CKII in transformed cells and in established cell lines was reduced to about the same basic level after treatment with heparin, a highly specific inhibitor of CKII activity. The activity of the cAMP-dependent protein kinase was virtually the same in fibroblasts and various human tumour cell lines investigated.Keywords
This publication has 27 references indexed in Scilit:
- Phorbol ester and diacylglycerol induce protein phosphorylation at tyrosineNature, 1983
- DIFFERENCES IN GROWTH REGULATION OF NORMAL AND TUMOR CELLS*Annals of the New York Academy of Sciences, 1982
- Multisite phosphorylation of glycogen synthase from rabbit skeletal muscleFEBS Letters, 1982
- Similar effects of platelet-derived growth factor and epidermal growth factor on the phosphorylation of tyrosine in cellular proteinsCell, 1982
- Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cellsCell, 1981
- Selective inhibition of a cyclic nucleotide‐independent protein kinase (G‐type casein kinase) by naturally occurring glycosaminoglycansFEBS Letters, 1980
- Characterization of a normal avian cell protein related to the avian sarcoma virus transforming gene productCell, 1978
- Factors involved in initiation of haemoglobin synthesis can be phosphorylated in vitroNature, 1976
- Stimulated phosphorylation of non-histone phosphoproteins in SV-40 transformed WI-38 human diploid fibroblastsBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1975
- Glycogen synthetase kinase 2 (GSK 2); The identification of a new protein kinase in skeletal muscleFEBS Letters, 1974