1H and 13C n.m.r. studies of pseudo‐peptide analogues of the C‐terminal tetrapeptide of gastrin
- 1 November 1987
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 30 (5), 596-604
- https://doi.org/10.1111/j.1399-3011.1987.tb03370.x
Abstract
1H and 13C n.m.r. study of pseudo-peptide analogues of the C-terminal tetrapeptide of gastrin, obtained by replacing each peptide bond by a "reduced peptide bond", one at a time, e.g. Boc-Trp .psi. (CH2NH)Leu-Asp-Phe-NH2 2, Boc-Trp-leu.psi.(CH2NH)Asp-Phe-NH2 3, Boc-Trp-Leu-Asp.psi.(CH2NH)Phe-NH2 4, were reported. The CH2NH bond was completely characterized. 1H and 13C spectroscopic data were reported. It appeared from the present work that the modifications produced by the replacement of a peptide bond by a CH2NH bond were localized around the CH2NH.Keywords
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