A single point mutation confers tetrodotoxin and saxitoxin insensitivity on the sodium channel II
Open Access
- 18 December 1989
- journal article
- Published by Wiley in FEBS Letters
- Vol. 259 (1), 213-216
- https://doi.org/10.1016/0014-5793(89)81531-5
Abstract
A single point mutation of the rat sodium channel II reduces its sensitivity to tetrodotoxin and saxitoxin by more than three orders of magnitude. The mutation replaces glutamic acid 387 with a glutamine and has only slight effects on the macroscopic current properties, as measured under voltage‐clamp in Xenopus oocytes injected with the corresponding cDNA‐derived mRNA.Keywords
This publication has 29 references indexed in Scilit:
- Molecular cloning of a putative tetrodotoxin-resistant rat heart Na+ channel isoform.Proceedings of the National Academy of Sciences, 1989
- Primary structure and functional expression of a mammalian skeletal muscle sodium channelNeuron, 1989
- A rat brain na+ channel α subunit with novel gating propertiesNeuron, 1988
- Primary structure of rat brain sodium channel III deduced from the cDNA sequenceFEBS Letters, 1988
- Functional expression of cloned cDNA encoding sodium channel IIIFEBS Letters, 1988
- Patch clamp characterization of sodium channels expressed from rat brain cDNAEuropean Biophysics Journal, 1987
- Expression of functional sodium channels from cloned cDNANature, 1986
- MOLECULAR PROPERTIES OF VOLTAGE-SENSITIVE SODIUM CHANNELSAnnual Review of Biochemistry, 1986
- Existence of distinct sodium channel messenger RNAs in rat brainNature, 1986
- Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequenceNature, 1984