COMPLEMENTING MHC‐ AND NON‐MHC‐LINKED GENES AND RESISTANCE TO AVIAN SARCOMA VIRUS‐INDUCED TUMOURS IN INBRED LINES OF CHICKENS
- 1 June 1981
- journal article
- research article
- Published by Wiley in International Journal of Immunogenetics
- Vol. 8 (3), 215-223
- https://doi.org/10.1111/j.1744-313x.1981.tb00759.x
Abstract
Schmidt-Ruppin Rous sarcoma virus, subgroup B (SR-RSV-B), was inoculated into the wingwebs of chickens from three partially congenic inbred lines, G-B1, G-B2 and G-B3, homozygous for different MHC (B region) haplotypes (genotypes =B1/B1, B2/B2 and B3/B3 respectively). All birds developed tumours but only the G-B2 line resisted progressive tumour growth. Birds from lines G-B1 and G-B3 approached 100% susceptibility to progressive tumour growth, whereas most (G-B1 x G-B3) F1 hybrids were resistant to tumours induced by SR-RSV-B. The association of the resistance trait in F1 hybrids with genes of the B region was investigated by testing progeny of (G-B1 x G-B3) x G-B1 F1 and (G-B1 x G-B2) x G-B3 F1 backcross matings. Approximately 27% of the backcross population was resistant to SR-RSV-B-induced tumours and these resistant offspring were predominantly of the B1/B3 phenotype. We interpret these results to mean that resistance to progressive tumour growth involves complementation between genes (allelic or at separate loci) linked to or within the B region and that resistance is effective only when the complementing B region genes act in concert with complementing genes which assort independently of the MHC. We suggest that complementing B region-linked genes are homologues of complementing murine H-2-linked Ir genes. The function of the B region in determining growth of sarcomas may therefore be analogous to that of Ir genes.This publication has 31 references indexed in Scilit:
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