The Problem of Breast-Cancer Prophylaxis

Abstract

With the advent of increased understanding about tumor-cell growth and with the successful drug treatment of lymphomas and leukemias, more and more attention has been focused on the possibility of increasing the cure rate of neoplasms by long-term chemotherapy as a prophylactic adjunct to primary surgical resection, It is clear that many operable patients cannot be cured by operation alone since micrometastases are often left behind, in time, their growth becomes manifest as clinical metastases, and cure becomes impossible. In patients with breast cancer, initial clinical and pathological presentations (such as size of the tumor and involvement of regional lymph . . .