THE INHIBITION BY CORTISONE OF THE CYTOTOXIC ACTIVITY OF PPD ON TUBERCULIN-HYPERSENSITIVE CELLS IN TISSUE CULTURE
Open Access
- 1 December 1952
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 96 (6), 549-554
- https://doi.org/10.1084/jem.96.6.549
Abstract
Using the roller tube method of tissue culture, it has been shown that cortisone and compound F inhibit the cytotoxic action of PPD upon macrophages from the splenic tissue of tuberculous guinea pigs. Pretreatment of the cells for 24 hours with hormones before exposure to PPD was found to be essential. Estrone and desoxycorticosterone glucoside had no protective activity. Certain advantages of the tissue culture method in studies of tuberculin hypersensitivity and possible mechanisms and implications of this protective action of cortisone are discussed.Keywords
This publication has 6 references indexed in Scilit:
- INVIVO OBSERVATIONS ON THE EFFECT OF CORTISONE ON EXPERIMENTAL TUBERCULOSIS, USING THE RABBIT EAR CHAMBER TECHNIQUEPublished by Elsevier ,1952
- THE HISTOLOGY OF THE TUBERCULIN REACTION AND ITS MODIFICATION BY CORTISONE1951
- Effect of Cortisone on Some Reactions of Hypersensitivity in Laboratory Animals.Experimental Biology and Medicine, 1950
- THE ABILITY OF ACTH AND CORTISONE TO ALTER DELAYED TYPE BACTERIAL HYPERSENSITIVITY1950
- Relation of Oxygen and Temperature in the Preservation of Tissues by RefrigerationExperimental Biology and Medicine, 1949
- Growth of Psittacosis Virus in Roller Tube Tissue Culture; Use an a VaccineThe Journal of Infectious Diseases, 1946