Effect of a Low‐protein Diet on Acetaldehyde Metabolism in Rats
- 1 January 1977
- journal article
- research article
- Published by Wiley in Acta Pharmacologica et Toxicologica
- Vol. 40 (1), 134-144
- https://doi.org/10.1111/j.1600-0773.1977.tb02061.x
Abstract
The effect of dietary changes on liver alcohol and aldehyde dehydrogenase activities as related to effects on ethanol and acetaldehyde metabolism was investigated. Feeding rats for 8 weeks on diets rich in carbohydrate or fat, but with normal protein content, induced minor changes relative to giving a balanced diet. A low-protein, high-carbohydrate diet (5 % and 80 % of calory content, respectively) caused a significant reduction of both alcohol and aldehyde dehydrogenase activities in the liver. The activity of the high-Km aldehyde dehydrogenase in the microsomal and soluble fractions appeared to be more reduced than that of the low-Km enzyme in the mitochondrial fraction. The tail blood acetaldehyde was significantly higher in rats on the protein deficient diet in spite of their reduced ethanol elimination rates. The results suggest that protein deficiency deranges acetaldehyde metabolism and may thus increase the possible contribution of acetaldehyde to the effects caused by ethanol metabolism.Keywords
This publication has 21 references indexed in Scilit:
- Acetaldehyde levels during ethanol oxidation: A diet-induced change and its relation to liver aldehyde dehydrogenases and redox statesLife Sciences, 1975
- Effects of long-term ethanol treatment on aldehyde and alcohol dehydrogenase activities in rat liverBiochemical Pharmacology, 1975
- Liver aldehyde and alcohol dehydrogenase activities in rat strains genetically selected for their ethanol preferenceBiochemical Pharmacology, 1975
- Acetaldehyde Oxidation by Hepatic Mitochondria: Decrease After Chronic Ethanol ConsumptionScience, 1975
- In vitro inhibition of protein synthesis in rat liver as a consequence of ethanol metabolismBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1974
- Alcoholic cardiomyopathy II. The inhibition of cardiac microsomal protein synthesis by acetaldehydeJournal of Molecular and Cellular Cardiology, 1974
- The effect of acetaldehyde on mitochondrial functionArchives of Biochemistry and Biophysics, 1974
- Ethanol and acetaldehyde metabolism in rat strains genetically selected for their ethanol preferenceBiochemical Pharmacology, 1973
- änderungen der Alkoholdehydrogenase-Aktivität in der Rattenleber durch Eiweißmangel und äthanolZeitschrift für Die Gesamte Experimentelle Medizin, 1970
- Influence of Thyroid Function on the Acetaldehyde Level of Blood and Liver of Intact Rats during Ethanol MetabolismActa Pharmacologica et Toxicologica, 1969