Alterations in Cerebral Blood Flow and Oxygen Consumption during Prolonged Hypocarbia
- 1 February 1986
- journal article
- research article
- Published by Springer Nature in Pediatric Research
- Vol. 20 (2), 147-150
- https://doi.org/10.1203/00006450-198602000-00010
Abstract
The effect of prolonged (2 h) hypocarbia on cerebral blood flow, oxygen delivery, extraction, and consumption was studied in eight, 1- to 4-day-old piglets. Hyperventilation to PaCO2 < 20 mm Hg acutely (30 min) decreased cerebral blood flow and oxygen oconsumption. Cerebral oxygen consumption was subsequently restored via increases in cerebral blood flow and thus, cerebral oxygen delivery. Cerebral oxygen extraction rose from a normocarbic baseline of 50 to 75% with acute hypocarbia and was maintained at this level. The percent decrease in blood flow to the cerebrum was greater than that to other brain regions during hypocarbia.This publication has 10 references indexed in Scilit:
- Cardiovascular and Catecholamine Changes After Administration of Pancuronium in Distressed NeonatesPediatrics, 1985
- Cerebral Blood Flow and Metabolism following Pancuronium Bromide in Newborn LambsPediatric Research, 1984
- The Effects of Variations in Paco2 on Brain Blood Flow and Cardiac Output in the Newborn PigletPediatric Research, 1984
- Efficacy and neurologic outcome of profound hypocapneic alkalosis for the treatment of persistent pulmonary hypertension in infancyThe Journal of Pediatrics, 1984
- The Effect of Hypocarbia on the Cardiovascular System of PuppiesPediatric Research, 1984
- Relative error and variability in blood flow measurements with radiolabeled microspheresAmerican Journal of Physiology-Heart and Circulatory Physiology, 1982
- Oxygen Delivery to the Brain Before and After BirthScience, 1982
- Effects of severe arterial hypocapnia on regional blood flow regulation, tissuePO2 and metabolism in the brain cortex of catsPflügers Archiv - European Journal of Physiology, 1981
- HYPERVENTILATION-INDUCED CEREBRAL HYPOXIAPublished by Elsevier ,1980
- Variations in mean cerebral blood flow under anesthesia at rest and during cortical activation.Stroke, 1977