The synthesis of N(τ)-(2-hydroxypropyl)histidine, N(τ)-(2-hydroxyethyl)histidine, and their deuteriated analogues

Abstract

The synthesis of N(τ)-(2-hydroxypropyl) histidine (1), N(τ)-(2-hydroxy[²H₅]propyl) histidine (2), N(τ)-(2-hydroxyethyl) histidine (3), and N(τ)-(2-hydroxy[²H₄]ethyl) histidine (4) by reaction of protected histidine derivatives with bromoacetone, bromo[²H₅]acetone, 2-benzyloxyethyl toluene-p-sulphonate (17), and 2-benzyloxy[1,1,2,2-²H₄]ethyl toluene-p-sulphonate (18), respectively, is described.