The Microbial Challenge to Pulp Regeneration
- 15 June 2011
- journal article
- review article
- Published by SAGE Publications in Advances in Dental Research
- Vol. 23 (3), 285-289
- https://doi.org/10.1177/0022034511405388
Abstract
Pulp regeneration is considered in cases where the dental pulp has been destroyed because of microbial irritation. Diverse oral and food-borne micro-organisms are able to invade the pulp space, form biofilm on canal walls, and infiltrate dentinal tubules. Prior to pulp regeneration procedures, the pulp space and dentinal walls need to be sufficiently disinfected to allow for and promote regeneration. The necessary level of disinfection is likely higher than that accepted for traditional endodontic therapy, because in traditional techniques the mere lowering of bacterial loads and prevention of bacterial access to periapical tissues is conducive to healing. Moreover, several of the non-specific antimicrobials used in traditional endodontic therapy may cause significant changes in remaining dentin that interfere with its inherent potential to mediate regeneration. Non-specific antimicrobials also suppress all microbial taxa, which may allow residual virulent micro-organisms to preferentially repopulate the pulp space. Therefore, it is important for endodontic pathogens to be studied by molecular methods that allow for a broad depth of coverage. It is then essential to determine the most effective protocols to disinfect the pulp space, with minimal disruption of remaining dentin. These protocols include the topical use of effective antibiotics, including newer agents that have demonstrated efficacy against endodontic pathogens.Keywords
This publication has 57 references indexed in Scilit:
- Analyzing Endodontic Infections by Deep Coverage PyrosequencingJournal of Dental Research, 2010
- Revascularization and periapical repair after endodontic treatment using apical negative pressure irrigation versus conventional irrigation plus triantibiotic intracanal dressing in dogs' teeth with apical periodontitisOral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, 2010
- Nanoparticle-based Endodontic Antimicrobial Photodynamic TherapyJournal of Endodontics, 2009
- The Effect of Age on Bacterial Penetration of Radicular DentinJournal of Endodontics, 2009
- Photodynamic Treatment of Endodontic Polymicrobial Infection In VitroJournal of Endodontics, 2008
- Outcome of primary root canal treatment: systematic review of the literature – Part 2. Influence of clinical factorsInternational Endodontic Journal, 2007
- Influence of residual bacteria on periapical tissue healing after chemomechanical treatment and root filling of experimentally infected monkey teethEuropean Journal of Oral Sciences, 2006
- Traumatic intrusion of permanent teeth. Part 2. A clinical study of the effect of preinjury and injury factors, such as sex, age, stage of root development, tooth location, and extent of injury including number of intruded teeth on 140 intruded permanent teethDental Traumatology, 2006
- Replantation of 400 avulsed permanent incisors. 3. Factors related to root growthDental Traumatology, 1995
- Tissue formation in the root canal following pulp removalEuropean Journal of Oral Sciences, 1971