Induction of Diabetes Insipidus in Adrenalectomized Dogs with Cortisone.

Abstract

High cortisone dosage in adrenalectomized dogs induces marked polyuria and polydipsia. The 24-hr. urine volume may exceed control values by 5- to 10-fold. The daily renal excretion of Na, Cl, and K is increased, but considering the quantity of water eliminated, the urine is very dilute. Pituitrin is effective in controlling the polyuria and polydipsia only when administered in large amts. The normal water balance was not re-restablished until long after cortisone injns. were discontinued.