Mode of Action of Phenaglycodol, A New Neurosedative Agent

Abstract

Phenaglycodol, a compound originally selected for clinical trial on the basis of its anticonvulsant and effective tranquiliz-ing actions, has been shown to have a quieting effect on mice, cats and monkeys. Its effects on blood pressure, respiration and ecg are minimal. In studies on selected reflex arcs it has been shown to be a selective depressant of polysynaptic pathways at the spinal and supraspinal level. After doses of phenaglycodol causing sedation but not sleep in cats, the eeg shows a pattern of 9-12 c/second synchronous activity at both surface and deep electrodes.