Failure of Chloroquine in Human Babesiosis (Babesia microti)

Abstract

The failure of a 3-wk course of chloroquine to eliminate an infection of B. microti acquired on Martha''s Vineyard [USA] led to tests of selected drugs in hamsters infected with the strain from this patient. The results showed response to several antitrypanosomal drugs (pentamidine and 4,4-diazoaminobenzamidine) but not to antimalarial drugs (chloroquine, sulfadiazine and pyrimethamine).