Prazosin: Preliminary Report and Comparative Studies with Other Antihypertensive Agents
- 11 May 1974
- Vol. 2 (5914), 298-300
- https://doi.org/10.1136/bmj.2.5914.298
Abstract
In a group of 14 hypertensive patients a 10-week course of treatment with prazosin 3-7·5 mg/day produced a significant reduction in mean blood pressure without serious side effects. The fall in diastolic pressure exceeded the response to a placebo by 10 mm Hg or more in 9 patients. The average decrease in diastolic pressure was similar to that produced by methyldopa 750 mg/day or propranolol 120-160 mg/day but the fall in systolic pressure was comparatively smaller, consistent with reported experimental work showing that the drug causes vasodilatation. The hypotensive effect of prazosin 1·5-3 mg/day combined with propranolol was significantly greater than that of propranolol alone and resulted in good control of blood pressure.Keywords
This publication has 3 references indexed in Scilit:
- Treatment of Essential Hypertension with Combined Vasodilation and Beta-Adrenergic BlockadeNew England Journal of Medicine, 1972
- Combined Therapy with Vasodilator Drugs and Beta-Adrenergic Blockade in HypertensionCirculation, 1972
- Application of a Radioimmunoassay for Angiotensin I to the Physiologic Measurements of Plasma Renin Activity in Normal Human Subjects1Journal of Clinical Endocrinology & Metabolism, 1969