Release of Permeability Factors from the Blood Platelet

Abstract

Summary Incubation of platelets with antigen-antibody complexes, thrombin, collagen, latex particles, ADP, AMP or aggregated human serum albumin is associated with aggregation of platelets and release of permeability factors into the ambient fluid. The permeability response was most intense with the platelet-antigen-antibody complex and platelet-thrombin mixtures. It is postulated that the increased permeability is due to release of histamine, serotonin and lysosomal enzymes from the aggregated platelets.