The Chromosome-Breaking Effect of Coumarin Derivatives in theAlliumTest
Open Access
- 1 January 1954
- journal article
- research article
- Published by Firenze University Press in Caryologia
- Vol. 6 (2-3), 134-150
- https://doi.org/10.1080/00087114.1954.10797467
Abstract
The authors have studied the chromosome-breaking effect of coumarin and 5 of its derivatives in the cytological test Allium. All 6 compounds have been found able to induce chromosome breakage during both the « physiological » and the « structural » effect. The configuration predominating during the physiological effect (action of the compounds on mitotic chromosomes) is the pseudochiasma, the origin of which is ascribed to sub-chromatid breakage (AVANZI 1950). Chromosome aberrations of various types, due to breakage and reunion in unsplit chromosomes in resting nuclei, are easily observed in « recovery » experiments following treatment with « mutagenic » concentrations of all 6 coumarins investigated.Keywords
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