In vitro assay of cell-mediated immunity: the inhibition of migration of sensitized human lymphocytes by HL-A antigens.
- 1 April 1970
- journal article
- Vol. 6 (4), 445-55
Abstract
Human blood lymphocytes from donors sensitized by skin grafting were inhibited in their migration from capillary tubes by antigens from the skin graft donor. Lymphocytes from non-sensitized human subjects showed no or a very slight inhibition with similar antigens. When confronted with cell antigens from individuals which did not possess any of the detectable HL-A specificities of the donor, the sensitized lymphocytes exhibited a marginal degree of inhibition (15·3±2·0%). The degree of migration inhibition increased to an average of 24·9±2·0% when the sensitized lymphocytes were confronted with one HL-A antigen similar to that of the immunizing donor. When there were two and three HL-A antigens involved, inhibition increased to 29·4±4·1% and 37·8±4·6%, respectively.This publication has 22 references indexed in Scilit:
- HL-A Antigens and GenesVox Sanguinis, 1969
- HL—A Antigens and GenesVox Sanguinis, 1969
- Differential effects of human granulocytes and lymphocytes on human fibroblasts in vitro.1968
- Lymphocytotoxic Antisera of Limited Iso‐Specificity After Skin Grafting in ManVox Sanguinis, 1968
- Human Lymphocyte Migration as a Parameter of HypersensitivityActa Medica Scandinavica, 1967
- Mechanism of a Reaction in Vitro Associated with Delayed-Type HypersensitivityScience, 1966
- Homograft Target Cells: Contact Destruction in vitro by Immune MacrophagesScience, 1966
- In vitro Studies on Homograft SensitivityNature, 1965
- The reaction of immunologically activated lymphoid cells against homologous target tissue cells in VitroJournal of Cellular and Comparative Physiology, 1963
- In vitro Cell Migration as a Model for Delayed Hypersensitivity.Experimental Biology and Medicine, 1962