The Glycoprotein of Vesicular Stomatitis Virus Is the Antigen That Gives Rise to and Reacts with Neutralizing Antibody
- 1 December 1972
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 10 (6), 1231-5
- https://doi.org/10.1128/jvi.10.6.1231-1235.1972
Abstract
The glycoprotein, but no other virion protein, of vesicular stomatitis virus was solubilized by the nonionic detergent Triton X-100 in low ionic strength buffer. The solubilized viral glycoprotein induced the synthesis of antibody that formed a single precipitin line with the glycoprotein and that neutralized the infectivity of the virus. The neutralizing activity of the antibody was efficiently blocked by purified glycoprotein.Keywords
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