A METHOD OF ASSAYING THE ANTI-TETANUS POTENCY OF DRUGS ON EXPERIMENTAL LOCAL TETANUS IN THE RABBIT
Open Access
- 1 September 1958
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 13 (3), 330-333
- https://doi.org/10.1111/j.1476-5381.1958.tb00913.x
Abstract
Local tetanus was induced in rabbits by the intramuscular injection of tetanus toxin. The relative potency of drugs which abolished the muscle spasm was determined using quantitative electromyography and the accuracy of the method tested with mephenesin and thiopentone. It is suggested that the method is suitable for screening new drugs for clinical use.Keywords
This publication has 1 reference indexed in Scilit:
- THE SITE OF ACTION OF THE TOXIN IN LOCAL TETANUSThe Lancet, 1952