Gastric Iodide and chloride Clearances in Dogs.

Abstract

Iodide and chloride clearances were determined in anesthetized and unanes-thetized dogs. The control gastric iodide clearance was 10-50 times greater than the chloride clearance. Iodide clearance could be 95% suppressed by anions known to block the thyroid iodide trap but chloride clearance was practically unchanged. In the presence of the blocking agent, gastric iodide and chloride clearances were similar. These data suggest at least 2 mechanisms for gastric secretion of iodide: (a) a specific iodide secretory system and (b) a non-specific mechanism in common with chloride secretion, which continues to function after blockade of (a).