Biosynthesis of Estrogens in Pregnant and Non-pregnant Guinea Pigs*
- 1 March 1978
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 102 (3), 966-972
- https://doi.org/10.1210/endo-102-3-966
Abstract
Guinea pig ovaries obtained from pregnant and non-pregnant animals, incubated in the presence of a NADPH-generating system, converted [3H]-dehydroepiandrosterone and [14C]testosterone to estradiol. Under the same conditions, no radioactive estrogen could be identified in adrenal and placental incubations. The rate of formation of estradiol from dehydroepiandrosterone was linear during the 30-min incubation. The initial rates of formation for estradiol were 415 .times. 10-13 and 10.4 .times. 10-13 M/min per g tissue for the ovaries from pregnant and non-pregnant guinea pigs, respectively. The formation of estrone was shown only in the pregnant animal, and the initial rate of formation was 36.0 .times. 10-13 M/min per g tissue. The major site of estrogen formation in both pregnant and non-pregnant guinea pigs is the ovary.This publication has 7 references indexed in Scilit:
- ESTRADIOL RECEPTORS IN FETAL COMPARTMENT1976
- OVARIAN SECRETION OF OESTRADIOL, OESTRONE, 20-DIHYDROPROGESTERONE AND PROGESTERONE DURING THE OESTROUS CYCLE OF THE GUINEA-PIGReproduction, 1973
- Steroid Hormone Transformations by Endocrine Organs from Pregnant Mammals. I. Estrogen Biosynthesis by Mammalian Placental Preparationsin Vitro1Endocrinology, 1966
- STEROIDS AND OTHER LIPIDS OF PREGNANT COW'S URINEJournal of Endocrinology, 1959
- Steroids and other lipids of pregnant goat's urineBiochemical Journal, 1957
- Effects of Corpora Lutea Removal and Replacement with Progesterone on Pregnancy in GoatsJournal of Animal Science, 1951
- The duration of pregnancy in guinea-pigs after removal and also after transplantation of the ovariesThe Anatomical Record, 1928