Background: More than 50% of patients with gastric cancer initially present with locally advanced or metastatic disease. In general, gastric cancer in an advanced or metastatic stage is regarded as incurable. Despite treatment with palliative chemotherapy, the median survival time is still limited and does not exceed 12 months. Case Report: We report on a patient with advanced and metastatic gastric cancer who received palliative surgery and subsequent palliative chemotherapy. Results: Complete remission occurred after R2 resection and palliative chemotherapy. The patient is now disease-free for 10 years after the end of chemotherapy. Conclusions: Palliative chemotherapy for metastatic gastric cancer may seldom lead to long-term clinical remission.