Inhibition of dimethylarginine dimethylaminohydrolase (DDAH) and arginine deiminase (ADI) by pentafluorophenyl (PFP) sulfonates
- 11 October 2005
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 44,p. 5563-5565
- https://doi.org/10.1039/b510709a
Abstract
A range of pentafluorophenyl (PFP) sulfonate esters derived from the reaction of PFP vinyl sulfonate and various nitrones are shown to have significant inhibitory activity against the bacterial enzymes DDAH and ADI.Keywords
This publication has 15 references indexed in Scilit:
- Selective Substrate-Based Inhibitors of Mammalian Dimethylarginine DimethylaminohydrolaseJournal of Medicinal Chemistry, 2005
- Searching for DDAH Inhibitors: S-Nitroso-l-homocysteine Is a Chemical LeadJournal of the American Chemical Society, 2005
- Crystal Structures of Arginine Deiminase with Covalent Reaction Intermediates: Implications for Catalytic MechanismStructure, 2004
- Structural Insight into Arginine Degradation by Arginine Deiminase, an Antibacterial and Parasite Drug TargetPublished by Elsevier ,2004
- Synthesis of Functionalized Sulfonamides via 1,3-Dipolar Cycloaddition of Pentafluorophenyl VinylsulfonateOrganic Letters, 2003
- Structure-Activity Relationships for Inhibition of Cysteine Protease Activity and Development of Plasmodium falciparum by Peptidyl Vinyl SulfonesAntimicrobial Agents and Chemotherapy, 2003
- INHIBITION OF NITRIC OXIDE SYNTHASE AS A POTENTIAL THERAPEUTIC TARGETAnnual Review of Pharmacology and Toxicology, 1999
- Vinyl Sulfonate Esters and Vinyl Sulfonamides: Potent, Irreversible Inhibitors of Cysteine ProteasesJournal of the American Chemical Society, 1998
- Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolaseBritish Journal of Pharmacology, 1996
- Inhibition of Constitutive and Inducible Nitric Oxide Synthase: Potential Selective InhibitionAnnual Review of Pharmacology and Toxicology, 1995