Cerebrospinal fluid inhibits Alzheimer β‐amyloid fibril formation in vitro
- 8 October 1993
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 34 (4), 631-633
- https://doi.org/10.1002/ana.410340422
Abstract
Alzheimer's disease is characterized by the deposition of β‐protein (Aβ) as amyloid. Recently, it was found that Aβ is a normal component of serum and cerebrospinal fluid. Synthetic peptides homologous to Aβ form amyloid‐like fibrils spontaneously in water or physiological solutions. Using a peptide homologous to Aβ1–40, we find that fibril formation is inhibited by the presence of cerebrospinal fluid.Keywords
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