Short Telomeres Are Associated With Increased Carotid Atherosclerosis in Hypertensive Subjects
- 1 February 2004
- journal article
- research article
- Published by Wolters Kluwer Health in Hypertension
- Vol. 43 (2), 182-185
- https://doi.org/10.1161/01.hyp.0000113081.42868.f4
Abstract
Recent studies have shown that individuals with shorter telomeres present a higher prevalence of arterial lesions and higher risk of cardiovascular disease mortality. As a group, patients with high blood pressure are at an increased risk for cardiovascular diseases. However, some hypertensive patients are more prone than others to atherosclerotic lesions. The main objective of this study was to examine the relationship between telomere length, as expressed in white blood cells, and carotid artery atherosclerotic plaques in hypertensive males. Data from 163 treated hypertensive men who were volunteers for a free medical examination were analyzed. Extracranial carotid plaques were assessed with B-mode ultrasound. Telomere length was measured from DNA samples extracted from white blood cells. The results of this study show that telomere length was shorter in hypertensive men with carotid artery plaques versus hypertensive men without plaques (8.17±0.07 kb versus 8.46±0.07 kb; P<0.01). Multivariate analysis s...Keywords
This publication has 13 references indexed in Scilit:
- Association between telomere length in blood and mortality in people aged 60 years or olderThe Lancet, 2003
- Extracellular Superoxide Dismutase Is a Major Antioxidant in Human Fibroblasts and Slows Telomere ShorteningJournal of Biological Chemistry, 2003
- Chronology Versus BiologyHypertension, 2002
- Endothelial Cell Senescence in Human AtherosclerosisCirculation, 2002
- Carotid plaques, but not common carotid intima–media thickness, are independently associated with aortic stiffnessJournal Of Hypertension, 2002
- Telomere shortening in atherosclerosisThe Lancet, 2001
- Oxidants, oxidative stress and the biology of ageingNature, 2000
- Oxidative stress and vascular damage in hypertensionCurrent Hypertension Reports, 2000
- Telomere length and replicative aging in human vascular tissues.Proceedings of the National Academy of Sciences, 1995
- Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for Senescence?Experimental Cell Research, 1995