Assessment of the in vitro activity against Bacteroides spp. of spectinomycin, metronidazole and clindamycin

Abstract

The activity of spectinomycin was dependent on CO₂ concentration, pH and medium composition, whereas metronidazole and clindamycin activities were unaffected by these factors. Significant regression lines were obtained for the latter two drugs using standard methods. Membrane filtration was used to determine the MBC of strains. A modification of this technique was used as an experimental model and gave information on drug activities which could be of value in assessing their relative clinical usefulness.