Phenolic Antioxidants from the Heartwood of Acacia confusa
- 29 June 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Agricultural and Food Chemistry
- Vol. 53 (15), 5917-5921
- https://doi.org/10.1021/jf050550m
Abstract
In the present study, the ethanolic extracts from the heartwood of Acacia confusa, a species indigenous to Taiwan, exhibit strong antioxidant effects. Among all the fractions from ethanolic extracts of heartwood, the EtOAc soluble fraction exhibits the best antioxidant activity. The 80% 1,1-diphenyl-2-picrylhydrazyl radical inhibitory activity by the EtOAc extract was observed at a concentration of 5 μg/mL, and at the same dosage there was a similar free radical scavenging activity for (−)-ascorbic acid and (+)-catechin, both of which are well-known antioxidants. In addition, the EtOAc extract also protects ΦX174 supercoiled DNA against strand scission induced by hydroxyl radical. Furthermore, following by column chromatography and reverse-phase high-performance liquid chromatorgrapy, 10 pure phenolic compounds, including three major antioxidants (3,7,8,3‘,4‘-pentahydroxyflavone, 7,8,3‘,4‘-tetrahydroxy-3-methoxyflavone, and 3,4,2‘,3‘,4‘-pentahydroxy-trans-chalcone) and a new flavonoid (3,7,8,3‘-tetrahydroxy-4‘-methoxyflavone), were isolated from the ethanolic extracts of A. confusa heartwood. Keywords: Acacia confusa; antioxidant; flavonoids; free radical; phenolic compoundsKeywords
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