The Intravenous Model of Murine Tuberculosis is Less Pathogenic Than the Aerogenic Model Owing to a More Rapid Induction of Systemic Immunity
- 1 April 1999
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 49 (4), 362-366
- https://doi.org/10.1046/j.1365-3083.1999.00522.x
Abstract
The detection of mRNA in the murine model of tuberculosis for key cytokines involved in protective immunity in the lung tissues revealed a much faster emergence of the interferon (IFN)-gamma response in the intravenous route than in the aerosol route of inoculation. This slower response in the lungs was associated with a stronger inflammatory response, resulting in large granulomatous structures and eventual tissue damage.Keywords
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