A Plasminogen Activator in Spontaneously Active Human Blood.

Abstract

Globulins were precipitated isoelectrically (ph 5.3) from human, fibrinolytically active blood obtained from cases of sudden anoxemic death and from living persons after electrically induced convulsions. Addition of plasminogen to these solns. yielded a large increase in plasmin content as detn. on a plas-minogen-free fibrin substrate. Normal fibrinolytical methods yield erroneous results because of the activation of the plas-minogen in the substrate. The plasminogen activator thus dem- onstrated differs from the tissue activator and is probably formed from a precursor in blood.