STUDIES ON THE RELATIONSHIP BETWEEN OVARIAN HORMONES AND UTERINE INFECTION
- 1 December 1959
- journal article
- research article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 19 (3), 274-281
- https://doi.org/10.1677/joe.0.0190274
Abstract
SUMMARY: Experiments to determine the role of the granulocyte system in uterine defence against bacterial infections have given the following results: (1) There were significant differences in the bacterial content of the uteri of oestrous and pseudopregnant rabbits as little as 2 hr following experimental infections. The uterus of oestrous animals was almost sterile 24 hr after such infections but, at this time, the uterus of pseudopregnant animals still contained some residual infection. (2) Ligation of the uterus in oestrous animals impeded drainage and prevented the escape of leucocytes and bacteria from the lumen. The leucocytes accumulated to form a sterile pyometritis similar to that observed in the non-ligated uterus of the pseudopregnant rabbit. (3) Mobilization of leucocyte occurred more rapidly in the uterus of the oestrous animal, and t was also shown that a highly significant negative relationship existed in oestrous animals between bacterial numbers and leucocyte numbers within the uterus following experimental uterine infections. The slower rate of leucocyte mobilization in pseudopregnant animals is thought to be the main factor responsible for the different bactericidal activities of the uteri of oestrous and pseudopregnant rabbits.Keywords
This publication has 12 references indexed in Scilit:
- STUDIES ON THE RELATIONSHIP BETWEEN OVARIAN HORMONES AND UTERINE INFECTIONJournal of Endocrinology, 1959
- The Influx of Leukocytes and Presence of Bactericidal Substances in Inoculated Uteri of Estrous and Pseudopregnant RabbitsJournal of Animal Science, 1958
- INVESTIGATIONS ON THE ENDOCRINE-CONTROLLED DEFENSE MECHANISM OF ESTROUS AND PSEUDOPREGNANT RABBIT UTERI1957
- FATE OF SPERMATOZOA IN THE UTERUS OF THE MOUSE AND RATJournal of Endocrinology, 1956
- Leukocytic Clusters on Epithelial Cells in Cervicovaginal Smears: A Presumptive Test for Trichomonas InfectionAmerican Journal of Clinical Pathology, 1956
- Observations on the Origin and Specific Function of the Histiocytes in the Female Genital TractFertility and Sterility, 1953
- Active and passive sensitization of the uterus of the cow in vivo against Trichomonas foetus antigen and the evidence for the local production of antibody in that siteEpidemiology and Infection, 1953
- A histological study of metrorrhagia in the virgin heiferJournal of Anatomy, 1948
- Uterine defense mechanism against infectionAmerican Journal of Obstetrics and Gynecology, 1945
- A study of the mucosa of the genital tract of the cow, with special reference to the cyclic changesJournal of Anatomy, 1930