Impact of sucrose level on storage stability of proteins in freeze-dried solids: I. correlation of protein–sugar interaction with native structure preservation
- 1 September 2009
- journal article
- research article
- Published by Elsevier in Journal of Pharmaceutical Sciences
- Vol. 98 (9), 3131-3144
- https://doi.org/10.1002/jps.21621
Abstract
No abstract availableKeywords
This publication has 35 references indexed in Scilit:
- Solid state chemistry of proteins: II. The correlation of storage stability of freeze‐dried human growth hormone (hGH) with structure and dynamics in the glassy solidJournal of Pharmaceutical Sciences, 2008
- Stability of lyophilized human growth hormoneInternational Journal of Pharmaceutics, 2008
- Infrared microscopy for in situ measurement of protein secondary structure during freezing and freeze-dryingJournal of Pharmaceutical Sciences, 2007
- Mechanism of protein stabilization by sugars during freeze-drying and storage: Native structure preservation, specific interaction, and/or immobilization in a glassy matrix?Journal of Pharmaceutical Sciences, 2005
- Effects of Types of Sugar on the Stabilization of Protein in the Dried StateJournal of Pharmaceutical Sciences, 2003
- Moisture effects on Protein—Excipient Interactions in Spray-dried Powders. Nature of Destabilizing effects of SucroseJournal of Pharmaceutical Sciences, 1999
- Interactions of Stabilizers with Proteins During Freezing and DryingPublished by American Chemical Society (ACS) ,1994
- Protein secondary structures in water from second-derivative amide I infrared spectraBiochemistry, 1990
- An infrared spectroscopic study of the interactions of carbohydrates with dried proteinsBiochemistry, 1989
- The Adsorption of Water by ProteinsJournal of the American Chemical Society, 1945