A COMPARISON OF THE OVARIAN CHANGES PRODUCED IN IMMATURE ANIMALS BY IMPLANTS OF HYPOPHYSEAL TISSUE AND HORMONE FROM THE URINE OF PREGNANT WOMEN

Abstract

Within certain limits, the weights of ovaries of young rats stimulated to precocious development by 1 to 3 day implants of rat anterior-hypophyseal tissue were roughly proportional to the amount of tissue implanted. Four times the minimal dose caused the ovaries to increase roughly 4 times in weight. Injections of extracts of urine of pregnant women. 160 times the minimal dose, caused the ovarian weight barely to treble. Distribution of the same amount of extract into smaller doses at short intervals or mixing the extract with cellular material to regulate the rate of absorption did not change the results appreciably. Injection for longer periods of time produced larger ovaries. The difference in ovarian weight resulting from implant and extract treatment was due mainh* to the difference in the number of follicles stimulated. The minimal effective implant treatment causes a more general follicular development than the minimal extract treatment whereby a small number of follicles were carried to the corpora lutea stage.