Interaction of Histamine, Serotonin and Heparin with Hexadimethrine Bromide, a Mast Cell Fragmentor

Abstract

Summary Animals partially depleted of their histamine and serotonin by pretreatment with 48/80 were rendered less sensitive to the toxic effects of hexadimethrine. Conversely, pretreatment of mice with imidazole increased the toxic effects of a subsequent injection of hexadimethrine. These results, coupled to our previous findings (1,2) suggest that some of the responses to hexadimethrine in certain laboratory animals may be mediated via histamine, serotonin and heparin release. It is probable that there are other factors which may be concerned in the over-all toxicologic and pharmacologic picture of this antiheparin agent.