PHYSIOLOGICAL DISPOSITION OF ANTIMONY AFTER ADMINISTRATION OF 124SB-LABELLED TARTAR EMETIC TO RATS MICE AND MONKEYS AND EFFECTS OF TRIS (P-AMINOPHENYL) CARBONIUM PAMOATE ON THIS DISTRIBUTION

Abstract

Tris(p-aminophenyl) carbonium (TAC) salts and certain antimonials have been shown to be more effective together against Schistosoma mansoni in mice than would be expected from the simple addition of their activities when given alone. Owing to the toxicity of antimonials, the therapeutic advantage of such synergistic effects would largely depend upon whether or not they occurred because the co-administration of TAC pamoate led to higher or more sustained levels of antimony in the blood or tissues. This study of the effect of TAC pamoate on the physiological disposition of 124sb was designed to give information on this important aspect. In general, co-administration of or pretreatment with TAC pamoate had no significant effect on the disposition of antimony. This indicates that the additive or synergistic effect of the 2 drugs against schistosomes is not due to higher or more sustained levels of antimony in the blood and tissues.