A New Synthetic Method for β-Substituted γ-Butyrolactones via Palladium-Catalyzed Reaction of 2-Butene-1,4-diol with Aryl and 1-Alkenyl Halides, and Subsequent Oxidation

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Abstract
The palladium-catalyzed reaction of 2-butene-1,4-diol with aryl and 1-alkenyl halides under phase-transfer conditions affords 4-substituted 2-hydroxytetrahydrofurans, which are oxidized to 4-substituted 2(3H)-dihydrofuranones (γ-butyrolactones).