Some Relationships Between Peripheral Monoamine Oxidase Inhibition and Brain 5-Hydroxytryptamine Levels in Rats.
- 1 July 1959
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 101 (3), 435-437
- https://doi.org/10.3181/00379727-101-24969
Abstract
A method of measuring activity of monoamine oxidase inhibitors as a function of suppression of 5-hydroxy-indoleacetic acid (5-HIAA) excretion is described. Increased excretion of 5-HIAA after 5-hydroxytryptamine (5-HT) is effectively blocked by orally administered iproniazid, JB-516, and several alkaloids. Correlation of these results with increased brain 5-HT is presented. Instances of non-correlation such as lack of effect of oral harmine on brain 5-HT with concomitant suppression of 5-HIAA excretion are discussed.Keywords
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