Gene transfer by means of cell fusion: II the mapping of 8 loci on human chromosome 1.by statistical analysis of gene assortment in somatic cell hybrids
Open Access
- 1 June 1977
- journal article
- research article
- Published by The Company of Biologists in Journal of Cell Science
- Vol. 25 (1), 39-57
- https://doi.org/10.1242/jcs.25.1.39
Abstract
A method is described which should permit determination of the order and spacing of genes on all human chromosomes by the analysis of just one set of man-mouse hybrid cells. This method is used to determine the map of 8 loci on human chromosome 1. A comparison of the statistical maps of chromosome 1 and of the X-chromosome with the cytogenetic maps of these chromosomes at metaphase indicates that the statistically derived distances between genes are related to the amount of Giemsa light-band material between the genes.This publication has 19 references indexed in Scilit:
- Preferential location of X-ray induced chromosome breakage in the R-bands of human chromosomesHereditas, 2009
- Silent allele as genetic basis of fucosidosisNature, 1975
- Synteny of the human loci for fumarate hydratase and UDPG pyrophosphorylase with chromosome 1 markers in somatic cell hybridsCytogenetic and Genome Research, 1974
- Assignment of the Second Locus of Adenylate Kinase to Chromosome 1p: Preliminary DataCytogenetic and Genome Research, 1974
- Linkage studies of enzyme markers in man-mouse somatic cell hybridsAnnals of Human Genetics, 1973
- Isoenzymes of adenylate kinase in human tissueBiochimica et Biophysica Acta (BBA) - Enzymology, 1972
- Characteristics of a Human Diploid Cell Designated MRC-5Nature, 1970
- A third phosphoǵlucomutase locus in manAnnals of Human Genetics, 1968
- Human Red Cell PeptidasesNature, 1967
- Selection of Hybrids from Matings of Fibroblasts in vitro and Their Presumed RecombinantsScience, 1964