Inverse agonism at G protein‐coupled receptors: (patho)physiological relevance and implications for drug discovery
Open Access
- 1 May 2000
- journal article
- review article
- Published by Wiley in British Journal of Pharmacology
- Vol. 130 (1), 1-12
- https://doi.org/10.1038/sj.bjp.0703311
Abstract
No abstract availableKeywords
This publication has 94 references indexed in Scilit:
- Human Interferon-γ–inducible Protein 10 (IP-10) Inhibits Constitutive Signaling of Kaposi's Sarcoma–associated Herpesvirus G Protein–coupled ReceptorThe Journal of Experimental Medicine, 1998
- Human Calcitonin Receptors Exhibit Agonist-Independent (Constitutive) Signaling ActivityEndocrinology, 1997
- Antipsychotics with inverse agonist activity at the dopamine D3 receptorJournal of Neural Transmission, 1996
- Further evidence that naloxone acts as an inverse opiate agonist: Implications for drug dependence and withdrawaLLife Sciences, 1996
- The effect of the oxytocin antagonists F314 and F792 on the in vitvo contractility of human myometriumBJOG: An International Journal of Obstetrics and Gynaecology, 1996
- Autoantibodies against Cardiac G-Protein-Coupled Receptors Define Different Populations with Cardiomyopathies but Not with HypertensionClinical Immunology and Immunopathology, 1994
- Agonist-independent inhibition of G protein activation by muscarinic acetylcholine receptor antagonists in cardiac membranesEuropean Journal of Pharmacology: Molecular Pharmacology, 1992
- Na+ regulation of formyl peptide receptor-mediated signal transduction in HL 60 cells. Evidence that the cation prevents activation of the G-protein by unoccupied receptorsEuropean Journal of Pharmacology: Molecular Pharmacology, 1989
- Guanine nucleotides modulate muscarinic receptor binding in the heartBiochemical and Biophysical Research Communications, 1979
- On the nature of allosteric transitions: A plausible modelJournal of Molecular Biology, 1965