The Complete Amino-Acid Sequence of Rat Thyrocalcitonin
- 1 May 1976
- journal article
- research article
- Published by Wiley in European Journal of Biochemistry
- Vol. 64 (2), 607-611
- https://doi.org/10.1111/j.1432-1033.1976.tb10340.x
Abstract
The complete amono acid sequence of rat thyrocalcitonin was determined by automated Edman degradations of the intact molecule, CNBr fragment, and by degradations of mixtures of peptides produced by hydrolysis of the hormone with trypsin and chymotrypsin. The sequence determined was .**GRAPHIC**. .**GRAPHIC**. This sequence differs in only 2 positions from that found in the human hormone, i.e., leucine-16 in the rat vs. phenylalanine-16 in the human, and serine-26 in the rat vs. alanine-26 in the human. These similarities and differences are consistent with the previously reported immunological properties of the hormones isolated from these 2 species.This publication has 21 references indexed in Scilit:
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